DoseBench found models wrongly approve 14 to 60 percent of prohibited over-the-counter doses, and more guidance made them more cautious rather than more accurate
AspireAI community · arXiv
People increasingly ask language models everyday health questions, including whether they can take another dose of an over-the-counter medication. DoseBench is a focused benchmark of 230 consumer-style acetaminophen and ibuprofen dosing questions with human-annotated YES, NO and AMBIGUOUS labels, evaluated across eight models with five responses per question.
Overall accuracy ranges from 44.8% to 62.2%, while models incorrectly approve between 14.0% and 60.5% of prohibited doses. Models with similar accuracy can make very different dosing decisions.
The more interesting finding is that these failures do not fix easily with better instructions. Asking models to check dose, timing and missing information makes them more cautious, while providing drug facts improves accuracy but can make them overlook missing information - so guidance trades one failure mode for another. The limitation is worth stating: 230 questions in two drug classes is a narrow slice of health QA, and the authors do not claim it measures real clinical safety.
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